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      • Charles Sophy, DO
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  • Clinical
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    • Faculty
      • Serhat Gumrukcu, MD, PhD
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      • Tung Nguyen
      • David Hardy, MD
      • Shimon Slavin, MD
      • Charles Sophy, DO
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  • Research
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      • Gumrukcu Lab
        • Dr. Serhat
        • Lab Members
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    • Fields
      • Cancer
      • Infectious Diseases
  • Clinical
    • Diseases
    • Clinical Studies
    • Experimental Treatments
  • Collaborations
  • About Us
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    • History
    • Leadership
    • Faculty
      • Serhat Gumrukcu, MD, PhD
      • Phillip Musikanth, MD
      • Tung Nguyen
      • David Hardy, MD
      • Shimon Slavin, MD
      • Charles Sophy, DO
  • News
  • Contact
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Welcome to Seraph Research Institute
Facebook
Twitter
Youtube
Instagram
Pinterest
  • Research
    • Labs
      • Gumrukcu Lab
        • Dr. Serhat
        • Lab Members
        • Publications
    • Fields
      • Cancer
      • Infectious Diseases
  • Clinical
    • Diseases
    • Clinical Studies
    • Experimental Treatments
  • Collaborations
  • About Us
    • Purpose
    • History
    • Leadership
    • Faculty
      • Serhat Gumrukcu, MD, PhD
      • Phillip Musikanth, MD
      • Tung Nguyen
      • David Hardy, MD
      • Shimon Slavin, MD
      • Charles Sophy, DO
  • News
  • Contact
Menu
  • Research
    • Labs
      • Gumrukcu Lab
        • Dr. Serhat
        • Lab Members
        • Publications
    • Fields
      • Cancer
      • Infectious Diseases
  • Clinical
    • Diseases
    • Clinical Studies
    • Experimental Treatments
  • Collaborations
  • About Us
    • Purpose
    • History
    • Leadership
    • Faculty
      • Serhat Gumrukcu, MD, PhD
      • Phillip Musikanth, MD
      • Tung Nguyen
      • David Hardy, MD
      • Shimon Slavin, MD
      • Charles Sophy, DO
  • News
  • Contact
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GUMRUKCU LAB

Welcome to the Gumrukcu Lab

The laboratory of Dr Serhat Gumrukcu is located at Seraph Medical Clinic and Surgery Center, Los Angeles, California.

Expertise and Research Interests

The Gumrukcu Lab studies gene and cell therapy particularly in the context of cancer (hematological and solid tumors), developing novel stem cell transplant methods for rare diseases, and innate molecular and cellular immunology in cancer and chronic infections like HIV/AIDS and HBV. The main objective is to develop better stem cell transplant and cell and gene therapy treatments for patients with cancer, rare genetic disorders, and infectious diseases.

In his past research, Dr Gumrukcu has developed a gene-modified autologous bone marrow transplant method that has a potential to facilitate increased engraftment in a non-myeloablative model. He has demonstrated the successful homing, engraftment and increased reconstitution capabilities of the modified bone marrow cells. The Gumrukcu Lab now focuses on creating disease-specific gene therapy vectors to harness the potential of this method. This has promising clinical use potential as an outpatient procedure in treating tens of different genetic disorders, as well as many cancers and HIV.

The current research in our laboratory focuses on studies to:

  • Understand genetic and intracellular mechanisms that contribute to the resistance of long-term control of HIV
  • Understand basic hematopoietic stem/progenitor cell (HSPC) biology and its changes in the event of gene modification
  • Understand clonal characteristics and clinical safety profile of gene-modified HSPCs
  • Understand mechanisms that contribute to graft-versus-tumor, graft-versus-leukemia or graft-versus-virus effects in allogeneic stem cell transplants and adoptive cell therapy models
  • Develop novel gene therapy methods and clinical protocols for cancer, HIV, and rare genetic diseases, especially enzyme deficiency disorders
  • Investigate safer, less toxic autologous HSPC transplant methods for patients with nonmalignant diseases
  • Develop novel gene and cell therapy protocols to induce rapid, disease-specific humoral and cellular immune responses in chronic infectious diseases
  • Study viral replication machinery to develop gene therapies that develop novel molecular host defense mechanisms

AREAS OF RESEARCH

SARS-CoV-2
Cancer
HIV/AIDS
Infectious Diseases
Gene Therapy for Rare Genetic Disorders
Immune Dysregulation & Autoimmunity


seraph research institute

Seraph Research Institute
2080 Century Park East
Suite 710
Los Angeles, CA 90067
United States

424-388-1025

310-747-6732

info@seraphinstitute.org

RECENT FEATURES

blue-iv-drip

Gene modified CD34+ cells with increased ALDH1 expression confers in vitro protection against cyclophosphamide

February 24, 2021
Important-Role-of-gd-T-Cells-in-Anti-SARS-CoV-2-Immune-Response2

Important Role of gd T Cells in Anti-SARS-CoV-2 Immune Response

November 13, 2020

JOURNAL ARTICLES

Glutamate-Cysteine Ligase Modifie Subunit Overexpression Confers Resistance Against Busulfan

September, 2020

Gene Modified CD34+ cells with increased ALDH1 expression confers in virtro protection against cyclophosphamide

August, 2020

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